Current Issue : October-December Volume : 2020 Issue Number : 4 Articles : 3 Articles
The present study appraised the hepatoprotective activity of few marketed products against carbon tetrachloride induced liver damage. Liver damage was induced by intraperitoneal administration of an equal mixture of carbon tetrachloride and liquid paraffin (50% v/v, 2.8 ml/kg) in Wistar rats once daily for two successive days and the extent of damage was studied by assessing the biochemical parameters such as Albumin, Bilirubin, Cholesterol, SGPT, SGOT and GGTP levels in serum. The marketed products like Livol, Liv. 52, Tefroli and Stimuliv were orally administered to the animals with hepatotoxicity induced by carbon tetrachloride and its effects on biochemical parameters were compared with each group treated animals. All the marketed products resulted in a significant reduction in serum hepatic enzymes when compared to rats treated with carbon tetrachloride alone. There was a significant increase in the serum albumin when compared to rats treated with carbon tetrachloride alone. In Conclusion, the findings of the present study suggest that different herbal products used as test compounds possesses potent hepatoprotective activity against CCL¬4 induced liver injury in rats....
This study was conducted to analyze isolation, structural elucidation of ethanol extraction of Leucas aspera Linn leaves [LAP] possess in vitro anti inflammatory. The present work which involves the Anti inflammatory activity of LAP were investigated by carrageenan induced paw edema assay [CIPEA] in rats and the chemical structures of the isolated compounds were established by Mass, FTIR, 1HNMR, 13CNMR and 2D COSY spectroscopic techniques. The results indicated that Leucas aspera Linn leaves reported significantly higher anti-inflammatory activity at dose of 100 and 200 mg/kg when compared to that of standard Celecoxib dose levels. However, the anti-inflammatory effect of single doses is having lower activities and the chemical structures of the isolated compounds from LAP were concluded that the expected structure is 5, 7, 4’, 5’-tetrahydroxy-8-methoxy-propylene-Apigenin (flavonoid)....
Amaranthus spinosus Linn. (Amaranthaceae) is commonly known as spiny amaranth. It is a perennial herb, native to tropical America and found throughout India in roadsides, waste places and fields. Amaranthus spinosus have been used in indigenous medicine for the cure of diuretic, antidiabetic, antipyretic, anti-snake venom, anti-leprotic, anti-gonorrheal, anti-inflammatory, anthelmintic, anti-androgenic and as an immunomodulator. The antidiabetic activity of the methanolic extract of Amaranthus spinosus leaves were evaluated in alloxan induced diabetic rats. The histological sections of the pancreas were observed to know the effect of Amaranthus spinosus in diabetic and non-diabetic rats. It has been observed that methanolic extract of Amaranthus spinosus leaves exhibited antidiabetic activity. Methanolic extract of the leaves at dose 400 mg/kg has shown significant decrease of blood glucose level (BGL) at 4th and 7th day of the study period. The results suggested that the methanolic extract of the leaves of Amaranthus spinosus at dose 400 mg/kg possess potent antidiabetic activity. Thus, it can be concluded that Amaranthus spinosus leaves are having potent antidiabetic activity. Chemical constituents present in the extracts might be responsible for this activity....
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